For example; if in Syria, the opposition had targeted Russian and Chinese investments, perhaps they could have forced Assad’s owners to deal with him.
It would not have been as easy as it can be in Egypt because the Russian companies are mostly state-owned; owned by the Russian government, so it is a different dynamic. But still, if they could have developed in that direction as a strategy, it certainly would have been more useful than what has happened.
If you target the supply chain that is feeding the regimes, and benefiting from them, you have a better chance of getting what you want.
As it is, the more limbs of the state you target, the more power and profit you give to the multinationals over your country. The more devastation you cause through war, the more opportunities you give them for reconstruction, for financing, for cheap labor, and of course, for more weapons sales.